Posts

Showing posts with the label fibrinolysis
  The work of Ronnee Strickland relating  Fibrinolysis to the Plasminogen–Plasmin System and Beyond: A Remarkable Growth of Knowledge, with Personal Observations on the History of Fibrinolysis. Liquid chromatography electrospray ionization mass spectrometry (MS) with a triple quadrupole MS was used to identify known and novel heterocyclic aromatic amines (HAAs) in human urine. The identities of 2-amino-3,8-dimethylimidazo[4, 5- f ]quinoxaline (8-MeIQx) and 2-amino-1-methyl-6- phenylimidazo[4,5- b ]pyridine (PhIP) were confirmed by their product ion spectra. The constant neutral loss scan mode was employed to probe for other analytes in urine that display the transition [M + H] +  → [M + H − CH 3 • ] +• , which is common to HAAs containing an  N -methylimidazo moiety, and led to the detection of a previously unreported isomer of 8-MeIQx [Holland, R., et al. (2004)  Chem. Res. Toxicol. 17 , 1121−1136]. We now report the identification of another novel HAA, 2-amino-1-methylimidazo[4,5- b